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First Wave BioPharma Scores Phase2b Milestone; First Patient Dosed Targeting Unmet Treatment For Ulcerative Proctitis And UPS (NASDAQ: FWBI) First Wave BioPharma (NASDAQ: FWBI) has reached another milestone, commencing its Phase2b trial evaluating topical niclosamide to treat ulcerative proctitis and ulcerative proctosigmoiditis. The news takes the FWBI value-proposition from excellent to compelling. Pre-market on Thursday, FWBI announced dosing the first patient in a Phase 2b clinical trial investigating a topical formulation of niclosamide (FW-UP) as a potential treatment for patients with ulcerative proctitis (UP) and ulcerative proctosigmoiditis (UPS). UP and UPS are two types of ulcerative colitis, a chronic inflammatory bowel disease (IBD) consisting of fine ulcerations in the inner mucosal lining of the large intestine that do not penetrate the bowel muscle wall. UPS causes inflammation in the colon and rectum, while UP is confined only to the rectum. Both are debilita...